Compound Alpha: Comparison of 2 Fasciolicide Formulations in Cattle

The efficacy of the 5-chloro-2-methylthio-6( 1 n a p t h y l o x y ) 1H-benzimidazole called compound alpha, formulated as boluses or suspension, was evaluated against adult Fasciola hepatica in cattle. Twenty-seven steers were infected, each with 600 metacercariae of F. hepatica. After 10 weeks of infection, the animals were divided into 3 groups of 9 animals each. Group 1 received boluses at 10 mg/kg p.o. Group 2 received an oral suspension of 10 mg/kg. Group 3 served as an untreated control. Efficacy was calculated on fluke reduction on the treated animals relative to the control. Results showed a 100% efficacy for both formulations.